New micro-encapsulation delivery system to redefine DAO deficiency treatment

adiDAO microencapsulated from AB Biotek HNH redefines DAO deficiency treatment by offering superior enzyme stability, which works in synergy with other bioactive ingredients.

A middle-aged woman holding a vitamin supplement capsule (Image: Juice Flair_Shutterstock)

AB Biotek Human Nutrition and Health (HNH) has launched adiDAO® microencapsulated, a new ingredient format that optimises the delivery of the diamine oxidase (DAO) enzyme and, for the first time, allows it to be combined with other functional ingredients .

DAO helps the body to break down dietary histamine, a molecule that is naturally present in all food types but is found in particularly high concentrations in fish, dairy products, cheese, and wine.

Increased levels of unmetabolised histamine in the blood stream may result in gastro-intestinal issues, skin conditions, lower urinary tract (LUTS) symptoms, fibromyalgia, migraine and attention deficit hyperactivity disorder (ADHD). DAO deficiency is one of the world’s most common enzyme-related metabolic disorders.

There is growing interest in solutions that enhance histamine degradation by increasing levels of DAO in the gut. However, DAO is sensitive to stomach pH, necessitating the use of delivery mechanisms that are gastro-resistant. In addition, DAO tends to interact with other bioactive ingredients in a way that diminishes its benefits.

Coating technologies solve the problem

AB Biotek HNH’s latest innovation offers a unique solution to both challenges. In adiDAO microencapsulated, the DAO is surrounded by two food-grade protective layers produced using a combination of coating technologies. These layers are specially designed to protect the DAO, optimising its delivery when it reaches the small intestine. The layers also help to prevent against undesirable interactions with other bioactive ingredients.

The technology creates new opportunities for developing innovative products in the pharmaceutical and nutraceutical spaces. For example, it will enable manufacturers to include DAO in anti-histamine and ADHD treatments, or to combine it with probiotics or prebiotics in supplements.

Compatible with various pharmaceutical actives in different concentrations, adiDAO microencapsulated can be used to create bespoke, targeted solutions, offering convenience and improve patient compliance. Other benefits include a simplified production process and reduced manufacturing costs versus traditional gastro-resistance coating methods.

Gerald Dard, MD at AB Biotek HNH, said: “Rising awareness of DAO deficiency and related health issues is driving demand for innovative solutions using DAO. Our adiDAO microencapsulated breaks new ground in this growing market, allowing manufacturers to combine other actives directly with DAO for the first time. It’s not just a flexible solution, but also a major technological leap forward with the potential to improve real outcomes for the many people affected by DAO deficiency.”

New adiDAO microencapsulated is suitable for tablets, stick packs, liquid suspension formats, gummies, and capsules.

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