R&D collaboration advances treatment of immune mediated diseases

Lead Pharma, a clinical stage pharmaceutical company that designs and develops medicines for the treatment of immune mediated diseases and cancer, has entered into a collaboration and licence agreement with Roche to develop oral small molecules to treat a broad range of immune mediated diseases.

In this single target research collaboration Lead Pharma and Roche will collaborate in research activities up to the selection of a pre-clinical candidate after which Roche will be responsible for further development and global commercialisation.

Agreement Image by Gerd Altmann from Pixabay
Lead Pharma has entered into a collaboration and licence agreement with Roche to develop oral small molecules to treat a broad range of immune mediated diseases

Terms of the agreement

Under the terms of the agreement, Lead Pharma will receive an upfront payment of €10 million, and will be eligible to receive research funding and pre-clinical milestone payments; total potential payments including research, development, regulatory and sales milestones may add up to an aggregate of €260 million, plus royalties on worldwide sales.

“Our ambition is to develop life-changing treatments for patients. We are delighted to team up with Roche to pursue this goal,” says Frans van den Berg, chief executive officer of Lead Pharma. “Partnering is a key element of our strategy, this collaboration is yet another validation of the value of Lead Pharma’s innovation power.”

Arthur Oubrie, chief scientific officer of Lead Pharma, added: “This is the second project we partner with one of the largest pharmaceutical companies under our Discover, Design and Deliver platform. Our rigorous target selection process, translational screening cascade, and smart medicinal chemistry have been essential to bring this project to this stage. We are keen to collaborate with our colleagues at Roche to bring this novel approach to patients.”

“We are committed to advancing innovative science and transformative medicines for people affected by different immune mediated diseases,” says James Sabry, global head, Roche Pharma Partnering. “We are looking forward to further building on our expertise in this field and collaborating with Lead Pharma, aiming to make a difference for those patients.”



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