The depigmenting potential of sulphur-containing peptides

Lightskin is a natural depigmenting active ingredient from Silab. It is obtained from a biotech process and is rich in sulphur-containing peptides known for their capacity to limit melanogenesis.

Sulphur-containing peptides are molecules known for their transversal ability to limit melanogenesis. For its new depigmenting active ingredient Lightskin, Silab selected the yeast Ogataea siamensis. The natural capacity of this yeast to produce sulphur-containing molecules constitutes a considerable selective advantage for its development in the phyllosphere of the medicinal plant Ervatamia coronaria.

This potential was then enhanced by Silab, using its expertise in biotechnologies to develop a unique process for bio-guiding the yeast to stimulate the production of large quantities of the molecules of interest.

Doubled depigmenting action

Thanks to the richness in bio-guided sulphur-containing peptides, the universal depigmenting action of Lightskin is doubled on Caucasian and Asian melanocytes, significantly limiting tyrosinase activity and melanin production.

This efficacy was also demonstrated in pro-pigmenting contexts of pollution (receptor related to pollution (AhR) inactivated) and glycation (expression of the receptor for AGEs inhibited). 

Cosmetic benefits

Lightskin was evaluated on Asian and Caucasian volunteers selected for the presence of pigment spots, and more specifically on their high level of AGEs (Caucasian panel) or their history of living in polluted environments (Asian panel). The results showed that the active ingredient at 2.5% reduces the appearance of spots after 56 days of treatment on both volunteer groups. Uniformity of the complexion was improved, and radiance revived. 91% of Asian volunteers stated that their complexion was more uniform and brighter, and their spots less visible.

With its targeted performance, Lightskin is a patented active ingredient recommended in all depigmenting care products at the amount of 0.25% to 2.50%. Available locally from Meganede, Lightskin is supplied in an aqueous solution and it is easy to formulate. It complies with biodiversity regulations and has a natural origin content of 98.8% (ISO 16128). Lightskin meets international cosmetic regulations requirements (in Europe, the United States, China and Japan etc.).

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