Webinar: Friday, 23 July 2021, 6:00 PM

Does T2DM, not elevated blood cholesterol, drive coronary atherosclerosis?

It has been known for generations that progressive arterial disease including coronary artery disease (CAD) is a key component of Type 2 diabetes mellitus (T2DM). Despite this, a key teaching in modern clinical medicine is that an elevated blood cholesterol concentration rather than the presence of T2DM is the more important therapeutic target for the management of CAD. The recently reported Women’s Heart Study from Boston found that, whereas the presence of T2DM increased coronary heart disease risk more than 10-fold, the contribution of an elevated blood cholesterol concentration was barely noticeable. Instead, other biochemical markers or insulin resistance including the Lipoprotein Insulin Resistance Score predicted a more than 6-fold increased risk. Since it is now proven that T2DM is not a chronic, progressive disease but can be put into “remission” with different dietary interventions, the conclusion must be that CHD can also be prevented by the same dietary interventions.

In this talk I will present the evidence that leads to these conclusions which have very important implications for the practice of clinical medicine.

I will also discuss the concept of “hyperinsulinaemia is T2DM”.

Presented by
Conrad Strydom

Conrad Strydom

  • Editor: Medical Academic
Prof Tim Noakes

Prof Tim Noakes

  • MBChB, MD and DSc (Med) in Exercise Science

Prof Noakes studied at the University of Cape Town (UCT), obtaining a MBChB degree and an MD andDSc (Med) in Exercise Science. He is now an Adjunct Professor at the Cape Peninsula University ofTechnology (CPUT), following his retirement from the Research Unit of Exercise Science and SportsMedicine.In 1995 he was a co-founder of the now prestigious Sports Science Institute of South Africa (SSISA). He has been rated an A1 scientist by the National Research Foundation of SA (NRF) for a third 5-year term. In 2008 he received the Order of Mapungubwe, Silver, from the President of South Africa for his “excellent contribution in the field of sports and the science of physical exercise”.

Prof Noakes has published more than 750 scientific books and articles. He has been cited more than 21 000 times in scientific literature and has an H-index of 77. He has won numerous awards over the years and made himself available on many editorial boards.

He has authored many books. In 2003 he received the UCT Book Award for Lore of Running (4thEdition), considered to be the “bible” for runners. Since 2011 he has written his autobiography, Challenging Beliefs: Memoirs of a Career, published Waterlogged: The serious problem ofoverhydration in endurance sports (in 2012), published The Real Meal Revolution (in 2013), co-authoredwith Jonno Proudfoot, David Grier and Sally-Ann Creed, and following that the child-focused versionof this book, Raising Superheroes (in 2015). The latter two are now also published overseas. In 2014he co-wrote Always Believe in Magic, with Kevin Musikanth and Jonathan Kaplan, which is the story ofthe UCT Ikey Tigers journey to winning the 2014 Varsity Cup. The Banting Pocket Guide was publishedin 2017, co-authored with Bernadine Douglas and Bridgette Allan and most recently he has co-authored Lore of Nutrition with Marika Sboros. This details his journey from prosecution to innocence.

Following the publication of the best-selling book, The Real Meal Revolution, he founded The Noakes Foundation, the focus of which is to raise funding to support high quality research of the eating plan described in the book.

He is now the co-founder and Chief Medical Director of the Nutrition Network and devotes a majority of his time to promoting the low carbohydrate high fat diet, especially for those with insulin resistance,and on raising funds for Eat Better South Africa! and research through The Noakes Foundation.

He is highly acclaimed in his field and, at age 71, is still physically active, taking part in races up to21kms.

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