GOLD 2023 COPD Guidelines and the role of Tiotropium
Join Medical Chronicle for a free, one-hour, CPD-accredited webinar on GOLD 2023 COPD Guidelines and the role of tiotropium. This webinar is sponsored by Glenmark and will be presented by Dr Richard Nellis Van Zyl-Smit.
Presented by
Claire Rush
Editor: Medical Chronicle
Dr Richard Nellis Van Zyl-Smit
The overarching theme of my research strategy is poverty related lung disease. Where poverty has its major influence on respiratory disease is the intersection between risk factors such as smoking, air pollution, HIV and respiratory disease such a TB, pneumonia and airways disease.
The areas of interest thus include smoking related lung disease, non-tobacco related airways disease (HIV, post-TB) and adolescent HIV associated respiratory diseases. The strategy to tackle these interwoven area is to be collaborative and translational from epidemiology evaluation/ bedside clinical issues to the basic science research bench and back:
Epidemiology- Understanding the prevalence and significance of non- tobacco related COPD with particular interest in post-TB lung disease associated COPD.
Structure and function. To correlate the abnormal lung function findings and radiology in patients with post tuberculous/biomass induced COPD to better define and inform treatment decisions.
Immunology. To explore the mechanistic interactions of tobacco/biomass/e-cigarette exposure on host immunity and inflammation in relation to pneumonia and tuberculosis.
Clinical/Policy. To develop appropriate smoking cessation strategies and treatment services within the African / low income context and to evaluate treatment options for non-tobacco related COPD.
Active laboratory research. I have extended my PhD research into the effects of tobacco smoke and electronic cigarettes on human responses to Mycobacterium. Projects have looked at the effect of mycobacterial strain immunogenicity on immune responses, nicotine receptor agonists (used in tobacco cessation) and receptor blockers. I am co- currently supervision a PHD project on pleural fluid diagnostics.
In collaboration with Professor Johnathan Grigg (Queen Mary’s London) we are investigating the effects of tobacco smoke, wood smoke and nicotine on tuberculous and pneumococcal infection.
Pharma sponsored research studies 2007 on going. I have participated in over 100 research studies as either sub-investigator or principal investigator over the past 10 years. I am currently the principal investigator (and national Principal investigator) on 16 clinical studies. These research studies have all been conducted at the UCT Lung Institute. The majority of the studies have been on asthma or COPD but have also included, TB vaccine, TB drug development, smoking cessation, cystic fibrosis, pulmonary fibrosis.
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The overarching theme of my research strategy is poverty related lung disease. Where poverty has its major influence on respiratory disease is the intersection between risk factors such as smoking, air pollution, HIV and respiratory disease such a TB, pneumonia and airways disease.
The areas of interest thus include smoking related lung disease, non-tobacco related airways disease (HIV, post-TB) and adolescent HIV associated respiratory diseases. The strategy to tackle these interwoven area is to be collaborative and translational from epidemiology evaluation/ bedside clinical issues to the basic science research bench and back:
Epidemiology- Understanding the prevalence and significance of non- tobacco related COPD with particular interest in post-TB lung disease associated COPD.
Structure and function. To correlate the abnormal lung function findings and radiology in patients with post tuberculous/biomass induced COPD to better define and inform treatment decisions.
Immunology. To explore the mechanistic interactions of tobacco/biomass/e-cigarette exposure on host immunity and inflammation in relation to pneumonia and tuberculosis.
Clinical/Policy. To develop appropriate smoking cessation strategies and treatment services within the African / low income context and to evaluate treatment options for non-tobacco related COPD.
Active laboratory research. I have extended my PhD research into the effects of tobacco smoke and electronic cigarettes on human responses to Mycobacterium. Projects have looked at the effect of mycobacterial strain immunogenicity on immune responses, nicotine receptor agonists (used in tobacco cessation) and receptor blockers. I am co- currently supervision a PHD project on pleural fluid diagnostics.
In collaboration with Professor Johnathan Grigg (Queen Mary’s London) we are investigating the effects of tobacco smoke, wood smoke and nicotine on tuberculous and pneumococcal infection.
Pharma sponsored research studies 2007 on going. I have participated in over 100 research studies as either sub-investigator or principal investigator over the past 10 years. I am currently the principal investigator (and national Principal investigator) on 16 clinical studies. These research studies have all been conducted at the UCT Lung Institute. The majority of the studies have been on asthma or COPD but have also included, TB vaccine, TB drug development, smoking cessation, cystic fibrosis, pulmonary fibrosis.